Details

Autor(en) / Beteiligte

• Kamanaka, Masahito
• Bettelli, Estelle
• Carrier, Yijun
• Oukka, Mohamed
• Weiner, Howard L
• Awasthi, Amit
• Flavell, Richard A
• Peron, Jean P S
• Kuchroo, Vijay K

Titel

A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells

Ist Teil von

• Nature Immunology, 2007-12, Vol.8 (12), p.1380-1389

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2007

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Regulatory T cells (T(reg) cells) expressing the transcription factor Foxp3 are key in maintaining the balance of immune homeostasis. However, distinct induced T regulatory type 1 (Tr1) cells that lack Foxp3 expression also regulate T cell function, mainly by producing the immunosuppressive cytokine interleukin 10 (IL-10). However, the factors required for the induction of IL-10-producing suppressive T cells are not fully understood. Here we demonstrate that dendritic cells modified by T(reg) cells induced the generation of IL-10-producing Tr1 cells. The differentiation of naive CD4+ T cells into IL-10-producing cells was mediated by IL-27 produced by the T(reg) cell-modified dendritic cells, and transforming growth factor-beta amplified the generation of induced IL-10+ Tr1 cells by IL-27. Thus, IL-27 and transforming growth factor-beta promote the generation of IL-10-producing Tr1 cells.