The Journal of immunology (1950), 2010-09, Vol.185 (6), p.3190-3198
2010
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Details
- Autor(en) / Beteiligte
- Titel
- An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
- Ist Teil von
- The Journal of immunology (1950), 2010-09, Vol.185 (6), p.3190-3198
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2010
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The aryl hydrocarbon receptor (AHR) has been known to cause immunosuppression after binding dioxin. It has recently been discovered that the receptor may be central to T cell differentiation into FoxP3(+) regulatory T cells (Tregs) versus Th17 cells. In this paper, we demonstrate that kynurenine, the first breakdown product in the IDO-dependent tryptophan degradation pathway, activates the AHR. We furthermore show that this activation leads to AHR-dependent Treg generation. We additionally investigate the dependence of TGF-beta on the AHR for optimal Treg generation, which may be secondary to the upregulation of this receptor that is seen in T cells postexposure to TGF-beta. These results shed light on the relationship of IDO to the generation of Tregs, in addition to highlighting the central importance of the AHR in T cell differentiation. All tissues and cells were derived from mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-1767eISSN: 1550-6606DOI: 10.4049/jimmunol.0903670Titel-ID: cdi_proquest_miscellaneous_851461428
- Format
- –
- Schlagworte
- Animals, Cell Differentiation - genetics, Cell Differentiation - immunology, Cell Line, Tumor, Cells, Cultured, Coculture Techniques, Dendritic Cells - enzymology, Dendritic Cells - immunology, Dendritic Cells - metabolism, Dose-Response Relationship, Immunologic, Indoleamine-Pyrrole 2,3,-Dioxygenase - chemistry, Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism, Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology, Kynurenine - chemistry, Kynurenine - metabolism, Kynurenine - physiology, Ligands, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Receptors, Aryl Hydrocarbon - deficiency, Receptors, Aryl Hydrocarbon - metabolism, Receptors, Aryl Hydrocarbon - physiology, Signal Transduction - immunology, T-Lymphocytes, Regulatory - cytology, T-Lymphocytes, Regulatory - immunology, T-Lymphocytes, Regulatory - metabolism, Transforming Growth Factor beta - physiology, Tryptophan - chemistry, Tryptophan - physiology