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The Search for Effective Treatment of Clostridium difficile Infection
Ist Teil von
The New England journal of medicine, 2011-02, Vol.364 (5), p.473-475
Ort / Verlag
United States: Massachusetts Medical Society
Erscheinungsjahr
2011
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Since 1996, the incidence of
Clostridium difficile
infection has more than doubled. Some estimates suggest that there may be up to 3 million cases each year in the United States. If that statistic is correct, it would make
C. difficile
infection the most common bacterial cause of diarrhea in the United States. With the rising incidence, we are seeing higher mortality associated with the disease, related to at least two factors: increasing virulence of the
C. difficile
strains and increasing host vulnerability.
C. difficile
infection is particularly problematic when three factors are aligned: coexisting conditions, including advanced age; disturbed intestinal . . .