Bulletin of experimental biology and medicine, 2010-09, Vol.149 (3), p.320-323
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Pharmacokinetics and Antitumor Effects of the Drug Containing TNF-α in Nanoparticles
- Ist Teil von
- Bulletin of experimental biology and medicine, 2010-09, Vol.149 (3), p.320-323
- Ort / Verlag
- Boston: Boston : Springer US
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Antitumor activity of TNF-α incorporated in nanoparticles (VLP-TNF-α) and dynamics of its accumulation and elimination from the blood and tumor tissue were studied in ICR mice. The VLP-TNF-α preparation exhibited higher antitumor activity compared to free TNF-α, presumably due to longer circulation of the cytokine in the blood and its more intensive accumulation by tumor tissue.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-4888eISSN: 1573-8221DOI: 10.1007/s10517-010-0937-9Titel-ID: cdi_proquest_miscellaneous_845764426
- Format
- –
- Schlagworte
- Animals, Antineoplastic Agents - administration & dosage, Antineoplastic Agents - pharmacokinetics, Antineoplastic Agents - pharmacology, Biomedical and Life Sciences, Biomedicine, Carcinoma, Ehrlich Tumor - drug therapy, Cell Biology, double-strand RNA, Drug delivery systems, Drugs, Ehrlich carcinoma, Injections, Intramuscular, Internal Medicine, Laboratory Medicine, Mice, Mice, Inbred ICR, Nanoparticles, Pathology, pharmacokinetics, Time Factors, Tumor necrosis factor, Tumor Necrosis Factor-alpha - administration & dosage, Tumor Necrosis Factor-alpha - pharmacokinetics, Tumor Necrosis Factor-alpha - pharmacology, tumor necrosis factor-α, Tumors, Vehicles