Details

Autor(en) / Beteiligte

• Schroeder, W.A.
• Shelton, J.Roger
• Shelton, Joan Balog
• Robberson, Barbara
• Babin, Donald R.

Titel

A comparison of amino acid sequences in the β-chains of adult bovine hemoglobins A and B

Ist Teil von

• Archives of biochemistry and biophysics, 1967-04, Vol.120 (1), p.124-135

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

1967

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The sequences of amino acids in the β-chains of adult bovine hemoglobins A and B have been partially determined and compared. Three differences in sequence are apparent at residues 15, 18, and 119 of the 145-residue chains. There is no evidence of other variation, although this has not been determined with certainty. In an earlier investigation, it was concluded that the α-chains of the two hemoglobins are probably identical in sequence. The multiple differences between these two chains are in contrast to the single difference between most human hemoglobin variants. The relationship between the two bovine hemoglobins is reminiscent of that between human hemoglobins A and A 2 or C Harlem, as well as between sheep hemoglobins A and B. The implications of these relationships are discussed.