Journal of pharmaceutical sciences, 1970-02, Vol.59 (2), p.278-280
1970
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Details
- Autor(en) / Beteiligte
- Titel
- Effect of Charge Shielding by Nonpolar Groups on the Partitioning of Quaternized Amines
- Ist Teil von
- Journal of pharmaceutical sciences, 1970-02, Vol.59 (2), p.278-280
- Ort / Verlag
- Washington: Elsevier Inc
- Erscheinungsjahr
- 1970
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- The methiodide salts of a number of tertiary organic bases were examined for their distribution properties between chloroform and water. An attempt was made to demonstrate whether the screening of ionic charge by nonpolar groups would substantially increase the lipid solubility of the methiodides. Comparison of a series of 2,6-versus 3,5-methyl-substituted N(-methylpiperidine methiodides revealed little difference in their partition coefficients. Syntheses are described for some previously unreported substituted piperidines.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-3549eISSN: 1520-6017DOI: 10.1002/jps.2600590236Titel-ID: cdi_proquest_miscellaneous_84471241
- Format
- –
- Schlagworte
- Amines, Amines - analysis, Amines - chemical synthesis, Amines, quaternized—partitioning, Charge shielding, Charge shielding, nonpolar groups, effect—quaternized amine partitioning, Chemical Phenomena, Chemistry, effect-quaternized amine partitioning, nonpolar groups, Partition coefficients-quaternized amines, quaternized-partitioning, Tertiary bases- synthesis