Details

Autor(en) / Beteiligte

• Hamza, Nawel
• Berke, Bénédicte
• Cheze, Catherine
• Le Garrec, Raphaële
• Lassalle, Régis
• Agli, Abdel-Nacer
• Robinson, Philip
• Gin, Henri
• Moore, Nicholas

Titel

Treatment of high fat diet induced type 2 diabetes in C57BL/6J mice by two medicinal plants used in traditional treatment of diabetes in the east of Algeria

Ist Teil von

• Journal of ethnopharmacology, 2011-01, Vol.133 (2), p.931-933

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Artemisia herba-alba or Centaurium erythraea extracts reduced plasma glucose, insulin, triglycerides and total cholesterol concentrations in C57BL/6J mice with high-fat diet induced type 2 diabetes. This conforts the traditional use of these plants in human established type 2 diabetes mellitus. Hydro-alcoholic extracts of Centaurium erythraea Rafn (CE), Gentianaceae and Artemisia herba-alba Asso (AHA), Asteraceae, medicinal plants used in traditional treatment of diabetes in north-eastern Algeria, were tested in established type 2 diabetes induced with a standardized high fat diet (HFD) in mice. After confirmation of diabetes (17th week), plant extracts were administered orally by gavage at a dose of 2g/kg daily for 18 weeks to male C57BL/6J mice fed HFD. Animals were weighed, food intake and plasma glucose measured weekly, insulin and lipid profile at study end. At 35 weeks, groups treated with AHA or CE vs. HFD control had a significant reduction in mean (±SD) fasting blood glucose concentrations (143.8±23.9 and 139.5±14.2 vs. 229.0±20.8mg/dL, p<0.05, respectively), triglyceride (18.9±11.1 and 16.0±6.5 vs. 62.8±18.3mg/dL, p<0.05), total cholesterol (1.2±0.1 and 1.2±0.3 vs. 1.8±1.1g/L, p<0.05) and serum insulin concentrations (1.7±0.7 and 0.9±0.7 vs. 3.3±14.3ng/mL, p<0.05). Plant extracts also markedly reduced insulin resistance as compared to HFD controls (AHA: 15.6±9.1, CE: 9.0±7.7 vs. HFD control 38.5±30.3, p<0.05). The plant extracts decreased calorie intake and had little effect on body weight or HDL-cholesterol. AHA has already been shown to have a antihyperglycaemic and antihyperlipidemic effect but this is the first demonstration of an effect of AHA and CE on established HFD-induced diabetes.