Details

Autor(en) / Beteiligte

• Stening, G. Frank
• Johnson, Leonard R.
• Grossman, Morton I.

Titel

Effect of Cholecystokinin and Caerulein on Gastrin- and Histamine-Evoked Gastric Secretion

Ist Teil von

• Gastroenterology (New York, N.Y. 1943), 1969-07, Vol.57 (1), p.44-50

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

1969

Quelle

MEDLINE

Beschreibungen/Notizen

• Secretion was collected from the Heidenhain pouches of 8 dogs, 4 having gastric fistulas as well. Cholecystokinin (CCK) given as an intravenous infusion of 4 units per kg-hr (gastric fistula open) or a rapid intravenous injection of 4 units per kg (no gastric fistula) markedly inhibited gastrin (0.8 g per kg-hr) stimulated secretion. The effect of a rapid intravenous injection of 4 units per kg of CCK on gastric secretion evoked by a histamine stimulus (no gastric fistula) depended on the dose of histamine. With low doses of histamine dihydrochloride (0.01 to 0.02 mg per kg-hr) some dogs showed inhibition, and others, slight stimulation or little change. CCK doubled the acid response to 0.04 mg per kg-hr of histamine diHCl and slightly increased that to 0.08 mg per kg-hr. The enhanced responses with CCK never significantly exceeded those obtained with maximal doses of histamine. Since CCK is not a pure substance the experiments were repeated with caerulein, a compound similar to CCK in both structure and action, and the effects were similar in both kind and magnitude. We conclude that CCK inhibits gastrin-stimulated secretion and increases secretion produced by intermediate doses of histamine.