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Neutral in vivo metabolites of cannabinol isolated from rat faeces
Ist Teil von
Journal of pharmacy and pharmacology, 1977-08, Vol.29 (8), p.487-490
Ort / Verlag
England
Erscheinungsjahr
1977
Quelle
MEDLINE
Beschreibungen/Notizen
The in vivo transformation of cannabinol (CBN) in the rat has been studied. Unchanged CBN and nine neutral mono-oxygenated and dioxygenated CBN metabolites have been identified. In the mono-oxygenated series the metabolites occurred in decreasing order of prominence as follows: 7-hydroxy-CBN, 4''-hydroxy-CBN, 1''-hydroxy-CBN, 2''-hydroxy-CBN, 3''-hydroxy-CBN, 5''-hydroxy-CBN and CBN-7-al. In the dihydroxylated metabolite series only 1'',7-dihydroxy-CBN and 4'',7-dihydroxy-CBN were found with the former as the more prominent metabolite.