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Calpain 10 gene and laryngeal cancer: A survival analysis
Head & neck, 2011-01, Vol.33 (1), p.72-76
Moreno-Luna, Ramón
Abrante, Antonio
Esteban, Francisco
González-Moles, Miguel Angel
Delgado-Rodríguez, Miguel
Sáez, María Eugenia
González-Pérez, Antonio
Ramírez-Lorca, Reposo
Real, Luis Miguel
Ruiz, Agustín
2011
Details
Autor(en) / Beteiligte
Moreno-Luna, Ramón
Abrante, Antonio
Esteban, Francisco
González-Moles, Miguel Angel
Delgado-Rodríguez, Miguel
Sáez, María Eugenia
González-Pérez, Antonio
Ramírez-Lorca, Reposo
Real, Luis Miguel
Ruiz, Agustín
Titel
Calpain 10 gene and laryngeal cancer: A survival analysis
Ist Teil von
Head & neck, 2011-01, Vol.33 (1), p.72-76
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Background Laryngeal carcinoma is a common upper respiratory tract cancer with different environmental and genetic factors involved in its development. Calpains are Ca2+‐dependent cysteine proteases that modulate cellular function. A novel association between calpain 10 (CAPN10) haplotypes and laryngeal cancer has been found recently. Therefore, the goal of this study was to analyze the contribution of CAPN10 alleles to laryngeal cancer survival. Methods Patients were recruited from southern Spain. Genotypes were determined using pyrosequencing technology. We analyzed CAPN10 UCSNP‐44, UCSNP‐43, UCSNP‐19, and UCSNP‐63 allelic distributions in 199 patients with unrelated laryngeal cancer. Survival curves were calculated from the date of the intervention to the date of death. Multivariate analyses were done using the Cox proportional risk model. Results UCSNP‐19, UCSNP‐43, and UCSNP‐44 were unrelated to survival in both univariate and multivariate analyses. However, for UCSNP‐63 genotype 12 a significant relationship was observed in multivariate analysis (hazard ratio [HR] = 2.73; 95% confidence interval [CI], 1.21–6.20). Conclusion CAPN10 UCSNP‐63 genotype 12 seems to be related with a worse prognosis in laryngeal cancer. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Sprache
Englisch
Identifikatoren
ISSN: 1043-3074, 1097-0347
eISSN: 1097-0347
DOI: 10.1002/hed.21404
Titel-ID: cdi_proquest_miscellaneous_839715195
Format
–
Schlagworte
Aged
,
Alleles
,
Analysis of Variance
,
Biological and medical sciences
,
Calcium
,
Calpain
,
Calpain - genetics
,
calpains
,
CAPN10
,
Cause of Death
,
Cohort Studies
,
Confidence Intervals
,
Cysteine proteinase
,
Development
,
DNA, Neoplasm - genetics
,
Female
,
Gene Expression Regulation, Neoplastic
,
Genetic factors
,
Genetic Predisposition to Disease
,
Genotypes
,
Haplotypes
,
Head
,
Humans
,
Kaplan-Meier Estimate
,
Laryngeal cancer
,
Laryngeal carcinoma
,
Laryngeal Neoplasms - genetics
,
Laryngeal Neoplasms - mortality
,
Laryngeal Neoplasms - therapy
,
Male
,
Medical sciences
,
Middle Aged
,
Multivariate Analysis
,
Neck
,
Otorhinolaryngology. Stomatology
,
Polymerase Chain Reaction
,
polymorphism
,
Polymorphism, Single Nucleotide
,
Prognosis
,
Proportional Hazards Models
,
Respiratory tract
,
Spain
,
Survival
,
Survival Analysis
,
Tumors
,
UCSNP-63
,
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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