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Contribution of postprandial glucose to excess hyperglycaemia in Asian type 2 diabetic patients using continuous glucose monitoring
Diabetes/metabolism research and reviews, 2011-01, Vol.27 (1), p.79-84
Wang, J.-S.
Tu, S.-T.
Lee, I.-T.
Lin, S.-D.
Lin, S.-Y.
Su, S.-L.
Lee, W.-J.
Sheu, Wayne H.-H.
2011
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Wang, J.-S.
Tu, S.-T.
Lee, I.-T.
Lin, S.-D.
Lin, S.-Y.
Su, S.-L.
Lee, W.-J.
Sheu, Wayne H.-H.
Titel
Contribution of postprandial glucose to excess hyperglycaemia in Asian type 2 diabetic patients using continuous glucose monitoring
Ist Teil von
Diabetes/metabolism research and reviews, 2011-01, Vol.27 (1), p.79-84
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2011
Quelle
MEDLINE
Beschreibungen/Notizen
Background Previous studies examining the contributions of fasting glucose (FG) and postprandial glucose (PPG) to glycated haemoglobin ($\hbox{HbA}_{{\rm 1c}}$) have yielded conflicting results. We aimed to clarify the contributions of PPG to hyperglycaemia in Asian type 2 diabetic patients using continuous glucose monitoring. Methods Continuous glucose monitoring was conducted in 121 non‐insulin‐using type 2 diabetic outpatients, who were divided into five groups according to quintiles of $\hbox{HbA}_{{\rm 1c}}$ (ranging from 5.7 to 12.7%). Glucose area under the curve (AUC) above a glucose value of 5.5 mmol/L 24 or 4 h after meals was defined as $\hbox{AUC}_{{\rm total}}$. Glucose AUC above FG or preprandial glucose levels was defined as $\hbox{AUC}_{{\rm PPG}}$. The contribution of PPG to hyperglycaemia was calculated as ($\hbox{AUC}_{{\rm PPG}}$/$\hbox{AUC}_{{\rm total}}$) × 100%. The contribution of FG or preprandial glucose was calculated as [($\hbox{AUC}_{{\rm total}} -$ $\hbox{AUC}_{{\rm PPG}}$)/$\hbox{AUC}_{{\rm total}}$] × 100%. Results The contribution of PPG to either 24‐h hyperglycaemia or 4‐h hyperglycaemia after meals was significantly higher than FG and preprandial glucose in the lowest quintile of $\hbox{HbA}_{{\rm 1c}}$ (both p < 0.001). However, no difference was observed in the other four quintiles. Peak PPG and glucose excursions were higher after breakfast than those after lunch and dinner (p < 0.01 for all comparisons). Conclusions In Asian patients with type 2 diabetes, PPG 24 and 4 h after meals was a predominant contributor to excess hyperglycaemia in well‐controlled patients and was equally important as FG or preprandial glucose in moderately to poorly controlled patients with mean $\hbox{HbA}_{{\rm 1c}}$ up to 10%. Copyright © 2010 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 1520-7552
eISSN: 1520-7560
DOI: 10.1002/dmrr.1149
Titel-ID: cdi_proquest_miscellaneous_835118102
Format
–
Schlagworte
Adult
,
Aged
,
Asian
,
Asian Continental Ancestry Group
,
continuous glucose monitoring
,
Diabetes Complications - metabolism
,
Diabetes Mellitus, Type 2 - metabolism
,
Fasting
,
Female
,
Glucose - metabolism
,
Glycated Hemoglobin A - metabolism
,
Humans
,
hyperglycaemia
,
Hyperglycemia - etiology
,
Hyperglycemia - metabolism
,
Male
,
Middle Aged
,
Postprandial Period - physiology
,
PPG
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