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Thyrotropin Releasing Hormone: Development of Inactivation System During Maturation of the Rat
Ist Teil von
Science (American Association for the Advancement of Science), 1976-07, Vol.193 (4251), p.403-405
Ort / Verlag
United States: American Association for the Advancement of Science
Erscheinungsjahr
1976
Quelle
MEDLINE
Beschreibungen/Notizen
Whereas thyrotropin releasing hormone is rapidly and extensively degraded by plasma of adult rats, no appreciable loss of biological or immunological activity is caused by plasma from rats 4 or 16 days old. The plasma of neonatal rats does not appear to contain an inhibitor of thyrotropin releasing hormone peptidase or a peptidase with altered substrate affinity. The development of an active peptidase in rat plasma suggests a physiological role for inactivation of thyrotropin releasing hormone.