Details

Autor(en) / Beteiligte

• KONDO, TAKAHITO
• TANIGUCHI, NAOYUKI
• KAWAKAMI, YOSHIKAZU
• IDE, HAJIME
• SAITO, KAZUO
• MURAO, MAKOTO

Titel

Human Erythrocyte Carbonic Anhydrase B and C in Chronic Obstructive Lung Disease

Ist Teil von

• The Tohoku Journal of Experimental Medicine, 1975, Vol.117(4), pp.351-356

Ort / Verlag

Japan: Tohoku University Medical Press

Erscheinungsjahr

1975

Quelle

MEDLINE

Beschreibungen/Notizen

• The levels of carbonic anhydrase B and C isozymes in human red cells were determined using a quantitative immunological technique in patients with chronic obstructive lung disease. A significant increase in the level of carbonic anhydrase B was observed in these patients, while the level of carbonic anhydrase C did not change substantially. Positive correlations were found between the level of carbonic anhydrase B and arterial CO2 tension and plasma HCO3- concentration. A negative correlation was observed between the levels of carbonic anhydrase B and blood pH. These findings suggest that the synthesis or degradation of carbonic anhydrase B isozyme is affected by arterial CO2 tension or plasma HCO3- concentration. The clinical significance was also discussed in relation to these isozyme levels in red cell.