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The structure-function relationships for the permeability of trabecular bone may have relevance for tissue engineering, total joint replacements, and whole bone mechanics. To investigate such relationships, we used a constant flow rate permeameter to determine the intrinsic permeability of trabecular bone specimens, oriented longitudinally or transversely to the principal trabecular orientation, from the human vertebral body (n=20), human proximal femur (n=12), and bovine proximal tibia (n=24). Overall, the intertrabecular permeability ranged from 2.68 x 10(-11) to 2.00 x 10(-8) m2. Significant negative nonlinear relations between intertrabecular permeability and volume fraction were found for each group except the longitudinal bovine proximal tibial specimens (r2=0.34-0.80). The average permeability ratio, a measure of the anisotropy, was 2.05, 6.60, and 23.3 for the human vertebral body, bovine tibia, and human femur, respectively. The permeability depended strongly on flow direction relative to the principal trabecular orientation (p<0.0001) and anatomic site (p <0.0001). In addition to providing a comprehensive description of intertrabecular permeability as a function of anatomic site and flow direction, these data provide substantial insight into the underlying structure-function relationships.