Details

Autor(en) / Beteiligte

• Talmage, Roy V.
• Doty, S.B.
• Yates, C.W.

Titel

The effect of temperature on the uptake of radioiodine by the thyroid gland of the frog, Rana pipiens

Ist Teil von

• General and comparative endocrinology, 1962-06, Vol.2 (3), p.266-272

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

1962

Quelle

ScienceDirect

Beschreibungen/Notizen

• The pattern of I 131 uptake by the thyroid of the frog, Rana pipiens has been studied. Despite the small size of the gland and the lack of an apparent function in the adult summer frog, the removal of radioiodine from blood by the thyroid appeared to follow a pattern similar to that reported for mammals with the exception that the maximum accumulation of radioactivity in the gland had not yet occurred 48 hours after injection of the isotope. In frogs maintained at 3°C for at least 24 hours before administration of the I 131, the accumulation of radioactivity in the gland occurred at a near normal rate for the first few hours; however, this was followed at the fifth hour by a marked decrease in the amount of radioactivity found in the gland. A similar sequence was observed when the frogs were maintained in a solution of 0.5% propylthiouracil for 5 days before injection of I 131. Thiocyanate administration prevented the uptake levels observed in the cold frogs during the first 6 hours by reducing I 131 uptake at each sampling period. It is suggested that both thiouracil and reduction in the environmental temperature inhibit the enzymatic oxidation of iodide to iodine in the gland, while thiocyanate reduces the uptake of iodide by thyroid tissue.