Details

Autor(en) / Beteiligte

• Hobbs, Donald C.
• Welch, Willard M.
• Short, Marvin J.
• Moody, William A.
• van der Velde, C. D.

Titel

Pharmacokinetics of thiothixene in man

Ist Teil von

• Clinical pharmacology and therapeutics, 1974-09, Vol.16 (3part1), p.473-478

Ort / Verlag

United States

Erscheinungsjahr

1974

Quelle

MEDLINE

Beschreibungen/Notizen

• A new specific and sensitive assay for thiothixene, using mass fragmentography, has been developed and used to measure plasma concentrations in psychotic patients on long‐term therapy. Drug plasma concentrations reach an early peak following an oral dose and decline slowly thereafter. Despite considerable differences in doses, peak plasma concentrations fall within a relatively narrow range, indicating that, during earlier ad;ustments of dose to achieve therapeutic control, optimum plasma concentrations were also being achieved.