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Characterization of Pitx2c expression in the mouse heart using a reporter transgene
Developmental dynamics, 2011-01, Vol.240 (1), p.195-203
Furtado, Milena B.
Biben, Christine
Shiratori, Hidetaka
Hamada, Hiroshi
Harvey, Richard P.
2011
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Furtado, Milena B.
Biben, Christine
Shiratori, Hidetaka
Hamada, Hiroshi
Harvey, Richard P.
Titel
Characterization of Pitx2c expression in the mouse heart using a reporter transgene
Ist Teil von
Developmental dynamics, 2011-01, Vol.240 (1), p.195-203
Ort / Verlag
New York: Wiley‐Liss, Inc
Erscheinungsjahr
2011
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
To aid in detection and tracking of cells targeted by the left‐right (LR) pathway in the heart throughout morphogenesis, expression from a Pitx2c‐lacZ transgene (P2Ztg) was analysed in detail. β‐galactosidase expression from P2Ztg was robust, allowing reliable visualisation of low‐level Pitx2c expression, and was virtually entirely dependent upon NODAL signalling in the heart. P2Ztg showed expression in trabecular and septal, as well as non‐trabecular, myocardium, and a strong expression bias in myocardium associated with individual endocardial cushions of the atrioventricular canal and outflow tract, which are essential for cardiac septation. Expression on the ventral surface of the outflow tract evolved to a specific stripe that could be used to track the future aorta during outflow tract spiralling and remodelling. Our data show that the P2Ztg transgene is a useful resource for detection of molecular disturbances in the LR cascade, as well as morphogenetic defects associated with other cardiac congenital disorders. Developmental Dynamics, 2011. © 2010 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1058-8388
eISSN: 1097-0177
DOI: 10.1002/dvdy.22492
Titel-ID: cdi_proquest_miscellaneous_821199422
Format
–
Schlagworte
Animals
,
Gene Expression Regulation, Developmental
,
Genes, Reporter - physiology
,
Heart - embryology
,
Heart Defects, Congenital - genetics
,
Heart Defects, Congenital - metabolism
,
heart development
,
Homeobox Protein PITX2
,
Homeodomain Proteins - genetics
,
Homeodomain Proteins - metabolism
,
laterality
,
Mesoderm - embryology
,
Mesoderm - metabolism
,
Mice
,
Mice, Inbred C57BL
,
Mice, Transgenic
,
Models, Biological
,
Morphogenesis - genetics
,
Myocardium - metabolism
,
Neural Crest - metabolism
,
P2Ztg
,
Pitx2c transgene
,
Reproducibility of Results
,
Transcription Factors - genetics
,
Transcription Factors - metabolism
,
Transgenes - genetics
,
Transgenes - physiology
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