Advanced materials (Weinheim), 2010-12, Vol.22 (47), p.5398-5403
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Bypassing Multidrug Resistance in Cancer Cells with Biodegradable Polymer Capsules
- Ist Teil von
- Advanced materials (Weinheim), 2010-12, Vol.22 (47), p.5398-5403
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2010
- Quelle
- Wiley Online Library All Journals
- Beschreibungen/Notizen
- Biodegradable polymer capsules with drug‐loaded multilayers were prepared through click chemistry via layer‐by‐layer assembly. The capsules can efficiently release incorporated drug by intracellular enzymatic degradation in both sensitive and resistant colorectal cancer cells in vitro. Endocytosis of drug‐loaded capsules leads to bypass of Pgp‐mediated multidrug resistance in cancer cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0935-9648eISSN: 1521-4095DOI: 10.1002/adma.201003162Titel-ID: cdi_proquest_miscellaneous_820957661
- Format
- –
- Schlagworte
- Antibiotics, Antineoplastic - therapeutic use, Biocompatible Materials - chemistry, Capsules - chemistry, Cell Line, Tumor, Colorectal cancer, Doxorubicin, Doxorubicin - therapeutic use, Doxorubicin - toxicity, Drug delivery, Drug Resistance, Neoplasm, Humans, Multidrug resistance, Neoplasms - drug therapy, Paclitaxel, Paclitaxel - therapeutic use, Paclitaxel - toxicity, Polymer capsules, Polymers - chemistry, Polymethacrylic Acids - chemistry, Polyvinyls - chemistry, Pyrrolidines - chemistry