European journal of pharmacology, 1973-10, Vol.24 (1), p.113-119
1973
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Effects of clonidine and l-dopa on spontaneous and evoked splanchnic nerve discharges
- Ist Teil von
- European journal of pharmacology, 1973-10, Vol.24 (1), p.113-119
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 1973
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Clonidine and l-dopa (after M.K. 486) reduced pressor responses evoked by submaximal high frequency stimulation of the sciatic nerve, and medullary and hypotahalamic pressor areas. Low frequency stimulation at these sites and in the cervical spinal cord evoked responses in the splanchnic nerve consiting of early and late components which were inhibited by clonidine and l-dopa. Piperoxan or yohimbine reversed these effects. It is suggested that α-adrenoreceptor activation at medullary and spinal sites exerts sympatho-inhibitory effects.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-2999eISSN: 1879-0712DOI: 10.1016/0014-2999(73)90122-2Titel-ID: cdi_proquest_miscellaneous_82088908
- Format
- –
- Schlagworte
- Animals, Blood Pressure - drug effects, Carbidopa - pharmacology, Cats, Clonidine, Clonidine - pharmacology, Dihydroxyphenylalanine - pharmacology, Electric Stimulation, Evoked Potentials - drug effects, Evoked potentials 1185 1544 V 2, Female, Heart Rate - drug effects, Hypothalamus - physiology, l-Dopa, Laminectomy, Male, Medulla Oblongata - physiology, Norepinephrine - pharmacology, Pressoreceptors - drug effects, Receptors, Adrenergic, Sciatic Nerve - physiology, Spinal Cord - physiology, Splanchnic Nerves - drug effects, Spontaneous splanchnic potentials, Stereotaxic Techniques, Sympatholytics - pharmacology, Yohimbine - pharmacology