Fertility and sterility, 2011, Vol.95 (1), p.46-49
2011
Details
- Autor(en) / Beteiligte
- Titel
- Discovery of a novel biomarker in the urine in women with endometriosis
- Ist Teil von
- Fertility and sterility, 2011, Vol.95 (1), p.46-49
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Objective To investigate whether proteins secreted in urine differ between women with and without endometriosis. Design Laboratory study using human urine. Setting University-based laboratory. Patient(s) Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s) Urine collection from women with and without endometriosis. Main Outcome Measure(s) Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s) On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s) Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0015-0282eISSN: 1556-5653DOI: 10.1016/j.fertnstert.2010.05.016Titel-ID: cdi_proquest_miscellaneous_820790213
- Format
- –
- Schlagworte
- Adult, Biological and medical sciences, Biomarker, biomarkers, Biomarkers - urine, Blotting, Western, endometriosis, Endometriosis - diagnosis, Endometriosis - urine, Female, Female genital diseases, Gynecology. Andrology. Obstetrics, Humans, hysteroscopy, Internal Medicine, Keratin-19 - urine, laparoscopy, mass spectrometry, Medical sciences, Non tumoral diseases, Obstetrics and Gynecology, patients, proteins, Proteomics, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Up-Regulation - physiology, urine, women