Fertility and sterility, 2011, Vol.95 (1), p.363-365
2011
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Details
- Autor(en) / Beteiligte
- Titel
- SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos
- Ist Teil von
- Fertility and sterility, 2011, Vol.95 (1), p.363-365
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 2011
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Oocytes fertilized with spermatozoa obtained from Septin 12+/– chimeric mice failed to develop beyond the morula stage after IVF and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa. Given that SEPT12 is expressed at the edge of the sperm nucleus in both humans and mice, we hypothesized the vital roles of Septin 12 in sperm head shaping, nuclear DNA condensation, and early embryonic development.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0015-0282eISSN: 1556-5653DOI: 10.1016/j.fertnstert.2010.07.1064Titel-ID: cdi_proquest_miscellaneous_820788576
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Cell Nucleus - pathology, Cell Nucleus - physiology, chimerism, condensation, DNA, embryogenesis, Embryonic Development - physiology, Female, Gynecology. Andrology. Obstetrics, humans, Infertility, Male - genetics, Infertility, Male - pathology, Internal Medicine, intracytoplasmic sperm injection, Male, Medical sciences, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, morula, Morula - pathology, nuclear genome, Obstetrics and Gynecology, oocytes, Pregnancy, Septin 12, Septins - deficiency, Septins - genetics, Sperm Head - pathology, Sperm Head - physiology, Sperm Injections, Intracytoplasmic, sperm nucleus damage, spermatozoa