Science (American Association for the Advancement of Science), 1973-10, Vol.182 (4107), p.78-79
1973
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Details
- Autor(en) / Beteiligte
- Titel
- Vitamin B12 and the megaloblastic development
- Ist Teil von
- Science (American Association for the Advancement of Science), 1973-10, Vol.182 (4107), p.78-79
- Ort / Verlag
- United States
- Erscheinungsjahr
- 1973
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In patients with vitamin B(12) deficiency, phytohemagglutinin-stimulated cultured lymphocytes had little or no thymidylate synthetase activity. Ample activity was found in such lymphocytes from normal individuals and patients with folic acid deficiency or pernicious anemia in remission. It therefore appears that the megaloblastosis that is associated with vitamin B(12) deficiency is related to low thymidylate synthetase activity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075DOI: 10.1126/science.182.4107.78Titel-ID: cdi_proquest_miscellaneous_82023116
- Format
- –
- Schlagworte
- Anemia, Pernicious - enzymology, Bone Marrow Cells, Carbon Isotopes, Erythrocytes, Folic Acid Deficiency - enzymology, Humans, Lectins - pharmacology, Lymphocytes - drug effects, Lymphocytes - enzymology, Methyltransferases - metabolism, Nucleosides - metabolism, Thymidylate Synthase - blood, Thymidylate Synthase - metabolism, Vitamin B 12 Deficiency - blood, Vitamin B 12 Deficiency - enzymology