Bulletin of experimental biology and medicine, 2010-10, Vol.149 (5), p.625-627
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Inhibitor of Indoleamine-2,3-Dioxygenase 1-Methyl-D-Tryptophan Can Stimulate the Growth of Immunogenic Tumors
- Ist Teil von
- Bulletin of experimental biology and medicine, 2010-10, Vol.149 (5), p.625-627
- Ort / Verlag
- Boston: Springer US
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We studied the effect of 1-methyl-D-tryptophan, an inhibitor of indoleamine-2,3-dioxygenase, on the growth of transplanted hepatocarcinoma-29 in C3HA mice. Hepatocarcinoma-29 transplanted into the thigh muscles undergoes immunological rejection in more than 50% non-syngeneic recipients. Chronic local administration of 1-methyl-D-tryptophan promotes progressive growth of the tumor in recipient mice leading to 100% animal death. The stimulating effect of 1-methyl-D-tryptophan on tumor growth is discussed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-4888eISSN: 1573-8221DOI: 10.1007/s10517-010-1009-xTitel-ID: cdi_proquest_miscellaneous_818644106
- Format
- –
- Schlagworte
- Animals, Biomedical and Life Sciences, Biomedicine, Carcinoma, Hepatocellular - physiopathology, Cell Biology, Enzyme Inhibitors - pharmacology, Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors, Internal Medicine, Laboratory Medicine, Male, Mice, Mice, Inbred C3H, Muscle Neoplasms - physiopathology, Neoplasm Transplantation, Pathology, Tryptophan, Tryptophan - analogs & derivatives, Tryptophan - pharmacology, Tumors