Bulletin of experimental biology and medicine, 2010-12, Vol.150 (1), p.75-78
2010
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Nitroxyl Antioxidant TPPA-TEMPO Increases the Efficacy of Antitumor Therapy on the Model of Transplantable Mouse Tumor
- Ist Teil von
- Bulletin of experimental biology and medicine, 2010-12, Vol.150 (1), p.75-78
- Ort / Verlag
- Boston: Boston : Springer US
- Erscheinungsjahr
- 2010
- Quelle
- SpringerLink
- Beschreibungen/Notizen
- Nitroxyl antioxidant 4-triphenylphosphonioacetamido-2,2,6,6-tetramethylpiperidine-1-oxyl (TPPA-TEMPO) was synthesized from 4-chloroacetamido-2,2,6,6-tetramethylpiperidine-1-oxyl chloride and triphenylphosphine. Systemic administration of TPPA-TEMPO in the subtoxic dose to mice with lymphosarcoma inhibited tumor growth, but did not prolong animal lifespan. Combined treatment with TPPA-TEMPO and cyclophosphamide increased the effi cacy of antitumor therapy: it prolonged animal lifespan and increased the number of recovered mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-4888eISSN: 1573-8221DOI: 10.1007/s10517-010-1073-2Titel-ID: cdi_proquest_miscellaneous_818640294
- Format
- –
- Schlagworte
- Active oxygen, Animals, Antimitotic agents, Antineoplastic agents, Antineoplastic Agents, Alkylating - therapeutic use, Antineoplastic Combined Chemotherapy Protocols, Antioxidants, Antioxidants - chemistry, Antioxidants - therapeutic use, Biomedical and Life Sciences, Biomedicine, Cell Biology, Cyclic N-Oxides - chemistry, Cyclic N-Oxides - therapeutic use, Cyclophosphamide, Cyclophosphamide - therapeutic use, Internal Medicine, Laboratory Medicine, LS lymphosarcoma, Lymphoma, Non-Hodgkin - drug therapy, Male, Mice, Mice, Inbred CBA, Neoplasm Transplantation, nitroxyl radicals, Pathology, therapeutics, TPPATEMPO, Tumors