Details

Autor(en) / Beteiligte

• Marsman, A. J. W.
• Van Der Hart, Mia
• Walig, C.
• Eijsvoogel, V. P.

Titel

Migration inhibition experiments with mixtures of human peripheral blood lymphocytes and guinea pig peritoneal exudate cells

Ist Teil von

• European journal of immunology, 1972-12, Vol.2 (6), p.546-550

Ort / Verlag

Weinheim: WILEY‐VCH Verlag GmbH

Erscheinungsjahr

1972

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Migration inhibition using mixtures of human peripheral blood lymphocytes and non‐sensitized guinea pig peritoneal exudate cells was demonstrable with purified protein derivative of tuberculin (PPD) and Candida albicans extract (CAE) when lymphocytes were obtained from individuals with a delayed type skin reaction to these antigens. No migration inhibition occurred when lymphocytes were used from skin test negative individuals. Furthermore it was found that lymphocytes from some skin test negative persons, which did not induce migration inhibition, showed, however, an increased DNA synthesis when cultured in vitro with PPD. This indicates that a dissociation between the results of migration inhibition, skin test and lymphocyte transformation can occur not only in patients with immune disorders, as has been described by other investigators, but also in healthy individuals.