Details

Autor(en) / Beteiligte

• Miura, Yuri
• Sato, Yuji
• Arai, Yasumichi
• Abe, Yukiko
• Takayama, Michiyo
• Toda, Tosifusa
• Hirose, Nobuyoshi
• Endo, Tamao

Titel

Proteomic analysis of plasma proteins in Japanese semisuper centenarians

Ist Teil von

• Experimental gerontology, 2011, Vol.46 (1), p.81-85

Ort / Verlag

England: Elsevier Inc

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• We performed proteomic analysis of plasma proteins in Japanese semisuper centenarians (SSCs) (> 105 years) and young controls (20-39 years), and found that 18 protein spots were altered in the plasma of SSCs. From peptide mass fingerprinting following in-gel digestion, it was demonstrated that paraoxonase/arylesterase 1 (PON 1) and apolipoprotein E were decreased, while haptoglobin β-chain, α 1-microglobulin, and clusterin precursor were increased in SSCs. Interestingly, proteins related to oxidative stress, PON1, haptoglobin, α 1-microglobulin, and clusterin, were altered in SSCs. These results suggest that systemic redox regulation is important for the longevity of SSCs. Overall, proteomics analysis is a powerful technique to search for useful biomarkers for future studies in gerontology and to characterize the individual proteins associated with successful aging of SSCs. ► Four proteins associated with oxidative stress regulation, paraoxonase/arylesterase 1, haptoglobin, a1-microglobulin, and clusterin, were altered in Japanese semisuper centenarians (>105 years) (SSCs). ► Systemic redox regulation is important for the longevity of SSCs. ► Proteomics analysis is a powerful technique to search for useful biomarkers to study gerontology and to characterize individual proteins in the successful aging of SSCs.