Details

Autor(en) / Beteiligte

• Hoelzl, Christine
• Knasmüller, Siegfried
• Wagner, Karl-Heinz
• Elbling, Leonilla
• Huber, Wolfgang
• Kager, Nina
• Ferk, Franziska
• Ehrlich, Veronika
• Nersesyan, Armen
• Neubauer, Oliver
• Desmarchelier, Aurélien
• Marin-Kuan, Maricel
• Delatour, Thierry
• Verguet, Clotilde
• Bezençon, Claudine
• Besson, Amélie
• Grathwohl, Dominik
• Simic, Tatjana
• Kundi, Michael
• Schilter, Benoît
• Cavin, Christophe

Titel

Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules

Ist Teil von

• Molecular nutrition & food research, 2010-12, Vol.54 (12), p.1722-1733

Ort / Verlag

Weinheim: Wiley-VCH Verlag

Erscheinungsjahr

2010

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Scope: Coffee is among the most frequently consumed beverages. Its consumption is inversely associated to the incidence of diseases related to reactive oxygen species; the phenomenon may be due to its antioxidant properties. Our primary objective was to investigate the impact of consumption of a coffee containing high levels of chlorogenic acids on the oxidation of proteins, DNA and membrane lipids; additionally, other redox biomarkers were monitored in an intervention trial. Methods and results: The treatment group (n=36) consumed instant coffee co-extracted from green and roasted beans, whereas the control consumed water (800 mL/P/day, 5 days). A global statistical analysis of four main biomarkers selected as primary outcomes showed that the overall changes are significant. 8-Isoprostaglandin F2α in urine declined by 15.3%, 3-nitrotyrosine was decreased by 16.1%, DNA migration due to oxidized purines and pyrimidines was (not significantly) reduced in lymphocytes by 12.5 and 14.1%. Other markers such as the total antioxidant capacity were moderately increased; e.g. LDL and malondialdehyde were shifted towards a non-significant reduction. Conclusion: The oxidation of DNA, lipids and proteins associated with the incidence of various diseases and the protection against their oxidative damage may be indicative for beneficial health effects of coffee.