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Being underweight may reduce your ability to mobilise peripheral blood stem cells
Ist Teil von
Transfusion and apheresis science, 2010-12, Vol.43 (3), p.365-367
Ort / Verlag
England: Elsevier Ltd
Erscheinungsjahr
2010
Quelle
Access via ScienceDirect (Elsevier)
Beschreibungen/Notizen
Abstract Being underweight is associated with a poorer outcome after haematopoietic stem cell transplantation (HSCT). We investigated whether nutritional status affects a patient’s ability to mobilise stem cells. Weights, heights, peripheral blood CD34 counts and total collected stem cells were collected on 305 patients. Those patients who were underweight had a lower median peripheral blood CD34 count than those who were not underweight (36.0 vs. 53.0 × 106 /L ( p = 0.0047)). However, the proportion of patients achieving a collection containing the minimum number of CD34 cells required to define a successful stem cell collection was similar in those who were underweight and those who were not. Therefore being underweight may reduce a patient’s ability to mobilise peripheral blood stem cells and, if confirmed, improving nutritional status may reduce the number of patients who fail to mobilise.