Details

Autor(en) / Beteiligte

• Crowther, Mark
• Avenell, Alison
• Culligan, Dominic J

Titel

Being underweight may reduce your ability to mobilise peripheral blood stem cells

Ist Teil von

• Transfusion and apheresis science, 2010-12, Vol.43 (3), p.365-367

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2010

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Abstract Being underweight is associated with a poorer outcome after haematopoietic stem cell transplantation (HSCT). We investigated whether nutritional status affects a patient’s ability to mobilise stem cells. Weights, heights, peripheral blood CD34 counts and total collected stem cells were collected on 305 patients. Those patients who were underweight had a lower median peripheral blood CD34 count than those who were not underweight (36.0 vs. 53.0 × 106 /L ( p = 0.0047)). However, the proportion of patients achieving a collection containing the minimum number of CD34 cells required to define a successful stem cell collection was similar in those who were underweight and those who were not. Therefore being underweight may reduce a patient’s ability to mobilise peripheral blood stem cells and, if confirmed, improving nutritional status may reduce the number of patients who fail to mobilise.