AIDS (London), 2010-10, Vol.24 (16), p.2581-2583
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Pharmacokinetics of etravirine, raltegravir and darunavir/ritonavir in treatment experienced patients
- Ist Teil von
- AIDS (London), 2010-10, Vol.24 (16), p.2581-2583
- Ort / Verlag
- Hagerstown, MD: Lippincott Williams & Wilkins
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Etravirine is an enzyme inducer and could lower the concentration of combined drugs. Ten HIV-1-infected patients with multiple treatment failure received raltegravir (400 mg, twice daily) and darunavir/ritonavir (600/100 mg, twice daily). Addition of etravirine (200 mg, twice daily) leads to a significant increase in raltegravir and darunavir trough concentrations (405 vs. 118 and 3837 vs. 2241 ng/ml) and darunavir area under the curve (AUC(12h)) (50 083 vs. 36 277 ng h/ml). All pharmacokinetic parameters appeared to be highly variable regardless to the addition of etravirine.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0269-9370eISSN: 1473-5571DOI: 10.1097/QAD.0b013e32833d89faTitel-ID: cdi_proquest_miscellaneous_815541638
- Format
- –
- Schlagworte
- Adolescent, Adult, AIDS/HIV, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antiviral agents, Biological and medical sciences, Darunavir, Drug Combinations, Female, HIV Infections - drug therapy, HIV Infections - metabolism, HIV Protease Inhibitors - administration & dosage, HIV Protease Inhibitors - pharmacokinetics, HIV-1, Human immunodeficiency virus, Human viral diseases, Humans, Infectious diseases, Male, Medical sciences, Middle Aged, Pharmacology. Drug treatments, Pyridazines - administration & dosage, Pyridazines - pharmacokinetics, Ritonavir - administration & dosage, Ritonavir - pharmacokinetics, Sulfonamides - administration & dosage, Sulfonamides - pharmacokinetics, Viral diseases, Viral diseases of the lymphoid tissue and the blood. Aids, Young Adult