Behavioural brain research, 2010-12, Vol.213 (2), p.323-327
2010
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Details
- Autor(en) / Beteiligte
- Titel
- The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss
- Ist Teil von
- Behavioural brain research, 2010-12, Vol.213 (2), p.323-327
- Ort / Verlag
- Shannon: Elsevier B.V
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The developmental onset of deficits in sensorimotor-gating was examined in the maternal immune activation (MIA) animal model of schizophrenia. Pre-pulse inhibition (PPI) deficits were evident in juvenile MIA rats. This parallels the sensorimotor-gating deficits observed in groups at high-risk of schizophrenia. PPI deficits were independent of maternal weight loss following the MIA manipulation, suggesting that this measure may not be a useful marker of treatment efficacy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0166-4328eISSN: 1872-7549DOI: 10.1016/j.bbr.2010.05.008Titel-ID: cdi_proquest_miscellaneous_815534123
- Format
- –
- Schlagworte
- Adult and adolescent clinical studies, Age Factors, Animals, Behavioral psychophysiology, Biological and medical sciences, Disease Models, Animal, Female, Fundamental and applied biological sciences. Psychology, Juvenile, Male, Maternal weight, Medical sciences, MIA, Poly I-C, Pre-pulse inhibition, Pregnancy, Prenatal Exposure Delayed Effects - immunology, Prenatal Exposure Delayed Effects - psychology, Psychology. Psychoanalysis. Psychiatry, Psychology. Psychophysiology, Psychopathology. Psychiatry, Psychoses, Rats, Schizophrenia, Schizophrenia - immunology, Schizophrenia - physiopathology, Schizophrenic Psychology, Sensorimotor-gating, Sensory Gating - physiology, Weight Loss