Biochemical pharmacology, 1971-09, Vol.20 (9), p.2137-2140
1971
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Details
- Autor(en) / Beteiligte
- Titel
- Correlation between in vitro and in vivo models in anti-inflammatory drug studies
- Ist Teil von
- Biochemical pharmacology, 1971-09, Vol.20 (9), p.2137-2140
- Ort / Verlag
- England: Elsevier Inc
- Erscheinungsjahr
- 1971
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Several hundred compounds which had undergone multiple anti-inflammatory testing provided the basis for comparing three in vitro and four in vivo models. Chi-square analysis for concordance of test results showed highly significant associations among the following: albumin denaturation, sulfhydryl-disulfide inter-change, aldehyde binding, broncho-constriction by bradykinin, and acute knee joint synovitis. Results of paw edema or cotton pellet granuloma tests were apparently independent of other test results.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-2952eISSN: 1873-2968DOI: 10.1016/0006-2952(71)90211-5Titel-ID: cdi_proquest_miscellaneous_81354481
- Format
- –
- Schlagworte
- Aldehydes - antagonists & inhibitors, Animals, Anti-Inflammatory Agents - pharmacology, Bradykinin - antagonists & inhibitors, Chemical Phenomena, Chemistry, Disulfides, Drug Evaluation, Preclinical, Edema - drug therapy, Granuloma - drug therapy, In Vitro Techniques, Methods, Models, Biological, Protein Binding - drug effects, Protein Denaturation - drug effects, Rats, Serum Albumin, Bovine - antagonists & inhibitors, Statistics as Topic, Sulfhydryl Compounds, Synovitis - drug therapy