Details

Autor(en) / Beteiligte

• Bendich, Adrianne
• D'Apolito, Patricia
• Gabriel, Edda
• Machlin, Lawrence J.

Titel

Interaction of Dietary Vitamin C and Vitamin E on Guinea Pig Immune Responses to Mitogens

Ist Teil von

• The Journal of nutrition, 1984-09, Vol.114 (9), p.1588-1593

Ort / Verlag

Bethesda, MD: Elsevier Inc

Erscheinungsjahr

1984

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Guinea pigs were fed semipurified diets with 0.2 g/kg vitamin C and either 0, 30 or 200 mg/kg all-rac-α-tocopheryl acetate or 10 mg/kg vitamin C and either 0, 30 or 200 mg/kg all-rac-α-tocopheryl acetate for 4 weeks. Animals were killed, and blastogenic responses of splenocytes to T- and B-cell mitogens were measured. Both T- and B-cell responses were significantly depressed in vitamin E-deficient guinea pigs when compared to responses from guinea pigs fed diets containing vitamin E. The two dietary levels of vitamin C examined did not affect the magnitude of these responses. The higher dietary vitamin C, however, increased the vitamin E content of the lung at all levels of vitamin E intake.