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A male child with chronic granulomatous disease (CGD) developed protracted axillary lymphadenopathy with liquefaction following a bacille Calmettle-Guérin (BCG) immunization. Except for phagocytic dysfunctions characteristic of the un derlying disease, immunological examinations were normal. The literature dealing with CGD cases with disseminated BCG infection was reviewed. It is concluded that the possibility of CGD should be considered in those who develop such adverse reactions to BCG immunization.