Details

Autor(en) / Beteiligte

• Channing, Cornelia P.
• Tanabe, Kiyoo
• Jones, Georgeanna Seegar
• Jones, Howard W.
• Lebech, Paul

Titel

Inhibin activity of preovulatory follicles of gonadotropin-treated and untreated women

Ist Teil von

• Fertility and sterility, 1984-08, Vol.42 (2), p.243-248

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

1984

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• In order to determine whether treatment of endocrinologically normal women with human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG) led to alternations in follicular fluid inhibin activity and steroids, both inhibin activity and steroid levels were measured in follicular fluid of 10 follicles of 9 women treated with hMG/hCG and in follicular fluid of 15 preovulatory follicles of 15 untreated women. The women were given 150IU hMG daily from day 3 until the serum estrogen levels were>300pg/ml, at which time hMG was discontinued and 10,000IU hCG was given 50 hours later. Follicular fluid was aspirated from all visible follicles 36 hours after hCG. Women treated with hMG/hCG had multiple (two to five) follicles containing 1.5 to 4.5ml of follicular fluid and a mature oocyte and elevated serum estrogen (400 to 800pg/ml) on the day after hCG treatment. At the time of follicular fluid recovery, there was more inhibin activity (204±14 U/10ml) in the hMG/hCG-stimulated follicles than in unstimulated follicles of a control group of women (65±14, mean±standard error, P<0.05). Follicular fluid from follicles of hMG/hCG-treated women had lower estrogen and progesterone levels, compared with normal preovulatory women. These data show that treatment of patients with hMG/hCG is associated with elevated follicular fluid inhibin activity.