Details

Autor(en) / Beteiligte

• OHTAKA, HIROSHI
• FUJIMOTO, YOSHIAKI
• YOSHIDA, KENJI
• KANAZAWA, TOSHIRO
• ITO, KEIZO
• TSUKAMOTO, GORO

Titel

Benzylpiperazine Derivatives. II. Syntheses and Cerebral Vasodilating Activities of 1-[ (3-Alkyl-3-hydroxy-3-phenyl) propyl] -4-benzylpiperazine Derivatives

Ist Teil von

• Chemical and Pharmaceutical Bulletin, 1987/07/25, Vol.35(7), pp.2782-2791

Ort / Verlag

Tokyo: The Pharmaceutical Society of Japan

Erscheinungsjahr

1987

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Analogs of 1-[ (3-alkyl-3-hydroxy-3-phenyl) propyl]-4- (2, 3, 4-trimethoxybenzyl) piperazine (1) were prepared and tested for cerebral vasodilating activity. It was found that the potency depends positively on the number of methoxyl groups on the benzyl moiety, and the homopiperazine analogs seem to be equipotent to the corresponding piperazines. From the standpoints of potency and ease of synthesis, 8k was selected for further study. Further analogs, which have various substituents in place of the benzyl moiety of 8k, were prepared and tested for cerebral vasodilating activity. These analogs were less potent than 8k. It was suggested that the benzyl moiety of 8k plays an important role in the high cerebral vasodilating activity.