Details

Autor(en) / Beteiligte

• Arvidsson, Lars Erik
• Johansson, Anette M
• Hacksell, Uli
• Nilsson, J. Lars G
• Svewnsson, K
• Hjorth, Stephan
• Magnusson, Tor
• Carlsson, Arvid
• Andersson, Bengt
• Wikstroem, Hakan

Titel

(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist

Ist Teil von

• Journal of medicinal chemistry, 1987-11, Vol.30 (11), p.2105-2109

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

1987

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• C1-Methylated derivatives of the potent 5-hydroxytryptamine (5-HT) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 1) were synthesized and tested for central 5-HT and dopamine receptor activity by use of a biochemical test method in rats. cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin (8) was found to be a 5-HT receptor agonist. The (+)-enantiomer of 8 had a potency equal to that of 1, whereas (-)-8 and the trans isomer (+/-)-9 were inactive.