Details

Autor(en) / Beteiligte

• Gembruch, U
• Bellmann, O
• Hansmann, M

Titel

Decreased alpha fetoprotein in maternal serum in relation to increased alpha fetoprotein in amniotic fluid in a case of fetal trisomy 21 associated with esophageal atresia

Ist Teil von

• Geburtshilfe und Frauenheilkunde, 1987-08, Vol.47 (8), p.569-571

Ort / Verlag

Germany

Erscheinungsjahr

1987

Quelle

MEDLINE

Beschreibungen/Notizen

• A subnormal maternal serum alpha-fetoprotein level associated with elevated alpha-fetoprotein level in amniotic fluid was found in a case of trisomy 21 combined with esophageal atresia in a fetus at 36 + 5 weeks of gestation. The significance of this observation is discussed in view of the possible biologic mechanisms resulting in maternal serum alpha-fetoprotein reduction in cases of fetal autosomal trisomies. The most likely hypotheses seem to be a reduced fetal alpha-fetoprotein production and/or an alteration of the placental regulation of the alpha-fetoprotein transfer from fetal to maternal blood via the placenta.