Details

Autor(en) / Beteiligte

• KARIN, M
• HASLINGER, A
• HOLTGREVE, H
• RICHARDS, R. I
• KRAUTER, P
• WESTPHAL, H. M
• BEATO, M

Titel

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

Ist Teil von

• Nature (London), 1984-04, Vol.308 (5959), p.513-519

Ort / Verlag

London: Nature Publishing

Erscheinungsjahr

1984

Quelle

MEDLINE

Beschreibungen/Notizen

• Deletion experiments have defined two stretches of DNA (genetic elements), lying close to the promoter for a human gene for metallothionein, that separately mediate the induction of the gene by heavy metal ions, particularly cadmium, and by glucocorticoid hormones. The element responsible for induction by cadmium is duplicated, yet a single copy is fully functional; the element responsible for induction by glucocorticoid hormones is coincident with the DNA-binding site for the glucocorticoid hormone receptor.