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Inherited partial trisomy #15 complicated by neuroblastoma
Ist Teil von
Cancer genetics and cytogenetics, 1984-02, Vol.11 (2), p.153-159
Ort / Verlag
New York, NY: Elsevier Inc
Erscheinungsjahr
1984
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
The proband in this study had multiple congenital malformations and a constitutional 46,XY,−13,+der(13),t(13;15)(q34;q23)mat chromosome complement. A bone marrow aspirate revealed neuroblastoma, and cytogenetic studies on tumor cells revealed, in addition to the partial trisomy #15 and probable partial monosomy #13, hypotetraploidy with a mean chromosome number of 82–84, including 3 or 4 copies of each autosome, 2 X chromosomes, no Y chromosome, and a marker. Translocations involving chromosomes #1, #2, #3, #7, and #14 were present, along with multiple double minutes. The possibility that the inherited partial trisomy #15 (and/or partial chromosome #13 monosomy) predisposed to neuroblastoma and additional chromosome changes in this tumor is discussed.