European journal of pharmacology, 1983-10, Vol.94 (1), p.59-72
1983
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Details
- Autor(en) / Beteiligte
- Titel
- Regulation of muscarinic agonist binding by cations and guanine nucleotides
- Ist Teil von
- European journal of pharmacology, 1983-10, Vol.94 (1), p.59-72
- Ort / Verlag
- Amsterdam: Elsevier B.V
- Erscheinungsjahr
- 1983
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- EDTA treatment of membrane preparations from rat brain and myocardium reduced the relative proportion of superhigh and high affinity binding sites for muscarinic agonists by up to 60%. This effect was partially or completely reversed by millimolar concentrations of Mg 2+ or Mn 2+. A number of multivalent metal cations gave qualitatively similar effects, yielding stimulation of agonist binding at low concentrations but inhibition at higher concentrations. The divalent cation-linked subpopulation of muscarinic agonist binding sites identified in this study appears to be the primary target for guanine nucleotide inhibition.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-2999eISSN: 1879-0712DOI: 10.1016/0014-2999(83)90442-9Titel-ID: cdi_proquest_miscellaneous_80805857
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Cations - physiology, Cholinergic system, Edetic Acid - pharmacology, Guanine Nucleotides - physiology, Guanylyl Imidodiphosphate - pharmacology, In Vitro Techniques, Kinetics, Magnesium - pharmacology, Male, Manganese - pharmacology, Medical sciences, Membranes - metabolism, Neuropharmacology, Neurotransmitters. Neurotransmission. Receptors, Oxotremorine - metabolism, Pharmacology. Drug treatments, Rats, Receptors, Muscarinic - metabolism, Sodium Chloride - pharmacology