Details

Autor(en) / Beteiligte

• Russell, Stephen W.
• Ward, Billy C.
• Baker, Norman F.

Titel

Obeliscoides cuniculi: Comparison of gastric lesions in rabbits with those of bovine ostertagiosis

Ist Teil von

• Experimental parasitology, 1970-01, Vol.28 (2), p.217-225

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

1970

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Four-month-old female New Zealand White rabbits were divided into 12 groups, each consisting of two inoculated animals and one control. All experimental rabbits were given 100,000 third-stage Obeliscoides cuniculi larvae by stomach tube, after which groups were necropsied during the next 22 days. Between postinoculation days 1 and 9, acute gastritis accompanied by weight loss attributable to a marked reduction in food and water consumption developed in experimental rabbits. During subsequent chronic stages of the disease, inoculated rabbits improved rapidly and clinically became essentially normal. Many gross and histopathologic changes similar to those of bovine ostertagiosis occurred in experimental rabbits. There were folding and thickening of the gastric mucosa caused by mucosal and submucosal edema, mononuclear and eosinophilic infiltrates of the lamina propria and submucosa, and extensive mucous-cell hyperplasia. The latter change resulted in the replacement of glandular epithelium and a subsequent rise in gastric pH. Primary nodules and epithelial cytolysis, two common lesions of bovine ostertagiosis, were not observed. Failure of the latter lesion to develop in rabbits may limit the usefulness of Obeliscoides cuniculi parasitism as a model of ostertagiosis, despite its many similarities to the bovine disorder.