Details

Autor(en) / Beteiligte

• Azzarone, B.
• Macieira-Coelho, A.
• Curatolo, L.
• Brouty-Boyé, D.
• Varnier, O.
• Donati, M. B.
• Morasca, L.

Titel

Fibrin Clot Retractile Activity in Normal, Established, and Tumorigenic Human Epithelial Cells in Culture

Ist Teil von

• JNCI : Journal of the National Cancer Institute, 1983-11, Vol.71 (5), p.879-885

Ort / Verlag

Cary, NC: Oxford University Press

Erscheinungsjahr

1983

Quelle

MEDLINE

Beschreibungen/Notizen

• Normal and established human epithelial cell lines obtained from the same organs were compared for their capacity to retract a fibrin clot. Fibrin clot retraction was maximal in normal epithelial cells, reduced in established nontumorigenic lines, and lost in tumorigenic cancer cell lines. Fibrin clot retraction efficiency seemed to be related to the degree of cellular spreading within the clot at the end of the test. Previous works and the present study suggest that fibrin clot retraction is correlated with some steps of cell transformation in vitro.