FEBS letters, 2010-06, Vol.584 (11), p.2445-2454
2010
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- Autor(en) / Beteiligte
- Titel
- Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis
- Ist Teil von
- FEBS letters, 2010-06, Vol.584 (11), p.2445-2454
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 2010
- Quelle
- Wiley Online Library All Journals
- Beschreibungen/Notizen
- Mycobacterium tuberculosis (Mtb) infection leads to the induction of the apoptotic response, which is associated with bacilli killing. The early secreted mycobacterial antigen ESAT-6 of Mtb has been shown to induce apoptosis in human macrophages and epithelial cells. In the present study, we demonstrate that the stimulation of human epithelial A549 cells by ESAT-6 induces the endoplasmic reticulum (ER) stress response. We observed that ESAT-6 treatment increases intracellular Ca2+ concentration, which results in ROS accumulation, and therefore induces the onset of ER stress-induced apoptosis. Our results uncover a novel apoptotic mechanism of ESAT-6 through ER stress responses in pathologic conditions such as tuberculosis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/j.febslet.2010.04.050Titel-ID: cdi_proquest_miscellaneous_807255803
- Format
- –
- Schlagworte
- Animals, Antigens, Bacterial - metabolism, Apoptosis, Bacterial Proteins - metabolism, Endoplasmic Reticulum - metabolism, Endoplasmic reticulum stress, Humans, Infection, Macrophages - metabolism, Mycobacterium tuberculosis, Mycobacterium tuberculosis - metabolism, Proteins - metabolism, Reactive Oxygen Species - metabolism, Tuberculosis - metabolism