Details

Autor(en) / Beteiligte

• Lowe, John A
• Seeger, Thomas F
• Nagel, Arthur A
• Howard, Harry R
• Seymour, Patricia A
• Heym, James H
• Ewing, Frank E
• Newman, Michael E
• Schmidt, Anne W

Titel

1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents

Ist Teil von

• Journal of medicinal chemistry, 1991-06, Vol.34 (6), p.1860-1866

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

1991

Quelle

MEDLINE

Beschreibungen/Notizen

• The design and synthesis of a series of potential atypical antipsychotic agents based on the structure of 1-naphthylpiperazine are described. The incorporation of dopamine antagonist activity into the parent structure was achieved with heterocyclic surrogates for the catechol moiety of dopamine. Compound 4b from this series showed a biochemical profile that translated to behavioral activity in the rat predictive of an antipsychotic agent with a low propensity to cause extrapyramidal side effects in man.