Details

Autor(en) / Beteiligte

• Gajtkowski, G A
• Norris, D B
• Rising, T J
• Wood, T P

Titel

Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex

Ist Teil von

• Nature (London), 1983-07, Vol.304 (5921), p.65-67

Ort / Verlag

England

Erscheinungsjahr

1983

Quelle

MEDLINE

Beschreibungen/Notizen

• Although the H2 subclass of histamine receptor has been revealed by classical pharmacological approaches, the direct identification of this adenylate cyclase-linked receptor has, despite much effort, remained elusive. Initial studies using 3H-metiamide and 3H-histamine and, subsequently, work from our own laboratory and others using 3H-cimetidine and 3H-ranitidine in various tissues, has shown the unsuitability of these ligands for labelling the H2 receptor. We report here our results using 3H-tiotidine, a more potent H2-antagonist than either cimetidine or ranitidine, and show that this ligand meets the criteria for labeling the H2 receptor in guinea pig cerebral cortex membranes.