Details

Autor(en) / Beteiligte

• SCHLÜTER, BERNHARD
• KÖNIG, WOLFGANG
• KÖLLER, MANFRED
• ERBS, GUNTHER
• MÜLLER, FRITZ E.

Titel

Differential Regulation of T- and B-Lymphocyte Activation in Severely Burned Patients

Ist Teil von

• The journal of trauma, 1991-02, Vol.31 (2), p.239-246

Ort / Verlag

Baltimore, MD: Williams & Wilkins

Erscheinungsjahr

1991

Quelle

MEDLINE

Beschreibungen/Notizen

• We studied the in vitro expression and regulation of the CD23 and CD25 (Tac) surface antigens by peripheral blood lymphocytes (PBL) from severely burned patients (burn injuries ranging from 25% to 72% TBSA) in order to evaluate T- and B-lymphocyte activation processes after thermal trauma. The spontaneous and cytokine (IL-4, IL-2)-induced expression of CD23 which represents a B-cell activation marker was significantly reduced during the second to fifth week postburn when compared to healthy donors. In contrast, CD25, which is expressed on activated T cells, showed a marked increase both spontaneously, indicating an in vivo activation, and after stimulation with IL-2 or PHA. Concomitantly, T-cell proliferation induced by PHA or Con A was suppressed. However, the number of T and B cells remained unchanged. The data demonstrate the impairment of early events in the lymphocyte program in severely burned patients. The activation of B cells is downregulated, since they become refractory to external helper signals. In addition, T cells are highly activated but fail to proceed to proliferation in response to mitogenic stimuli.