Science (American Association for the Advancement of Science), 1991-01, Vol.251 (4992), p.426-430
1991
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Details
- Autor(en) / Beteiligte
- Titel
- A genetic model for interaction of the homeodomain recognition helix with DNA
- Ist Teil von
- Science (American Association for the Advancement of Science), 1991-01, Vol.251 (4992), p.426-430
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 1991
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The Bicoid homeodomain protein controls anterior development in the Drosophila embryo by binding to DNA and regulating gene expression. With the use of genetic assays in yeast, the interaction between the Bicoid homeodomain and a series of mutated DNA sites was studied. These experiments defined important features of homeodomain binding sites, identified specific amino acid-base pair contacts, and suggested a model for interaction of the recognition alpha-helices of Bicoid and Antennapedia-class homeodomain proteins with DNA. The model is in general agreement with results of crystallographic and magnetic resonance studies, but differs in important details. It is likely that genetic studies of protein-DNA interaction will continue to complement conventional structural approaches
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1671176Titel-ID: cdi_proquest_miscellaneous_80430500
- Format
- –
- Schlagworte
- ADN, Amino Acid Sequence, Amino acids, Animals, Base Sequence, Binding sites, Binding sites (Biochemistry), Biological and medical sciences, Cellular biology, Chemical bases, Classical genetics, quantitative genetics, hybrids, Deoxyribonucleic acid, Developmental genetics, Diptera, DNA, DNA - metabolism, DNA binding proteins, DNA-Binding Proteins - genetics, DNA-Binding Proteins - metabolism, DROSOPHILA, Drosophilidae, EXPRESION GENICA, EXPRESSION DES GENES, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Genes, Genes, Homeobox - genetics, Genetic regulation, Genetics, Genetics of eukaryotes. Biological and molecular evolution, Gin, Homeodomain Proteins, Hydrogen bonds, Insect Hormones - genetics, Insect Hormones - metabolism, Invertebrata, MODELE, MODELOS, Models, Genetic, Molecular Sequence Data, Molecules, MUTACION, MUTATION, Oligonucleotides, Plasmids, Proteins, Trans-Activators, Transcription, Genetic, Yeasts