Details

Autor(en) / Beteiligte

• Schmall, Bernard
• Finn, Ronald D.
• Rapoport, Stanley I.
• Noronha, Jean G.
• Degeorge, Joseph J.
• Kiesewetter, Dale O.
• Simpson, Norman R.
• Larson, Steven M.

Titel

Synthesis of a fluorinated fatty acid, dl-erythro-9,10-[ 18F]difluoropalmitic acid, and biodistribution studies in rats

Ist Teil von

• International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1990, Vol.17 (8), p.805-809

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

1990

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• 9,10-Difluoropalmitic acid (DFPA) labeled with the cyclotron produced, positron emitting radionuclide 18F has been synthesized as a potential analogue of 9,10-[ 3H]palmitic acid, a fatty acid which has been used to study lipid metabolism in rat brain and pituitary. [ 18F]DFPA was prepared by the direct and stereoselective addition of [ 18F]F 2 to the double bond of cis-9,10-palmitoleic acid. The fluorination was carried out in FCCl 3 at −70 °C using a low concentration of F 2 (0.5%) in neon. [ 18F]DFPA has been obtained in radiochemical yields of 12–16% from end-of-bombardment (EOB) in approx. 2.5 h. Chemical and radiochemical purity exceeded 95%, and specific activities calculated to EOB ranged from 500 to 1000 mCi/mmol. [ 18F]DFPA crosses the blood-brain barrier and is incorporated into rat brain at about twice the level of that of 9,10-[ 3H]palmitic acid. The synthesis of [ 18F]DFPA permits us to study the biological disposition and metabolism of a vicinal-difluoro fatty acid.