The Journal of cell biology, 2004-02, Vol.164 (4), p.487-492
2004
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Details
- Autor(en) / Beteiligte
- Titel
- Greatwall Kinase: A Nuclear Protein Required for Proper Chromosome Condensation and Mitotic Progression in Drosophila
- Ist Teil von
- The Journal of cell biology, 2004-02, Vol.164 (4), p.487-492
- Ort / Verlag
- United States: Rockefeller University Press
- Erscheinungsjahr
- 2004
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Mutations in the Drosophila gene greatwall cause improper chromosome condensation and delay cell cycle progression in larval neuroblasts. Chromosomes are highly undercondensed, particularly in the euchromatin, but nevertheless contain phosphorylated histone H3, condensin, and topoisomerase II. Cells take much longer to transit the period of chromosome condensation from late G2through nuclear envelope breakdown. Mutant cells are also subsequently delayed at metaphase, due to spindle checkpoint activity. These mutant phenotypes are not caused by spindle aberrations, by global defects in chromosome replication, or by activation of a caffeine-sensitive checkpoint. The Greatwall proteins in insects and vertebrates are located in the nucleus and belong to the AGC family of serine/threonine protein kinases; the kinase domain of Greatwall is interrupted by a long stretch of unrelated amino acids.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9525eISSN: 1540-8140DOI: 10.1083/jcb.200310059Titel-ID: cdi_proquest_miscellaneous_80168738
- Format
- –
- Schlagworte
- Adenosine Triphosphatases - metabolism, Amino acids, Animals, Brain - cytology, Brain - metabolism, Caffeine - metabolism, Cell cycle, Cells, Cells, Cultured, Cellular biology, Chromosomes, Condensation, Cyclins, DNA-Binding Proteins - metabolism, Drosophila, Drosophila melanogaster - embryology, Drosophila melanogaster - enzymology, Drosophila melanogaster - genetics, Drosophila Proteins - genetics, Drosophila Proteins - metabolism, Fungal Proteins - genetics, Fungal Proteins - metabolism, Genes, Histones - metabolism, Humans, Mitosis, Mitosis - physiology, Multiprotein Complexes, Mutation, Neuroblasts, Neurons, Neurons - cytology, Neurons - physiology, Nuclear Proteins - genetics, Nuclear Proteins - metabolism, Plant Proteins - genetics, Plant Proteins - metabolism, Protein Kinases - genetics, Protein Kinases - metabolism, Protein-Serine-Threonine Kinases - genetics, Protein-Serine-Threonine Kinases - metabolism, Proteins, RNA Interference, Spindle Apparatus - metabolism