Details

Autor(en) / Beteiligte

• KAMBAM, J. R
• PARRIS, W. C. V
• NAUKAM, R. J
• FRANKS, J. J
• RAMA SASTRY, B. V

Titel

In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities

Ist Teil von

• Canadian journal of anaesthesia, 1990-11, Vol.37 (8), p.916-919

Ort / Verlag

Toronto, ON: Canadian Anesthesiologists' Society

Erscheinungsjahr

1990

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The in vitro effects of two metabolites of inhalational anaesthetics, fluoride and bromide, on pseudocholinesterase (PCHE) and acetylcholinesterase (ACHE) activities in the blood samples of seven healthy patients were studied. The PCHE and ACHE activities were determined by kinetic spectrophotometric methods. Fluoride at the levels achieved with clinical concentrations of enflurane and sevoflurane (25-75 microM.L-1) inhibited PCHE activity by 28-65 per cent (P less than 0.01) and ACHE activity by less than five per cent (P greater than 0.05). Bromide at the levels achieved with clinical concentrations of inhalational anaesthetics had no significant effect on either PCHE or ACHE activity. We recommend caution when succinylcholine and/or ester type local anaesthetics are used in the immediate postoperative period following enflurane or sevoflurane anaesthesia. We also recommend that blood drawing for PCHE activity be delayed at least until 24 hr following enflurane or sevoflurane anaesthesia.